Electrophysiological effects of orexin/hypocretin on nucleus accumbens shell neurons in rats: an in vitro study.

@article{Mukai2009ElectrophysiologicalEO,
  title={Electrophysiological effects of orexin/hypocretin on nucleus accumbens shell neurons in rats: an in vitro study.},
  author={Katsuyuki Mukai and Juhyon Kim and Kazuki Nakajima and Yutaka Oomura and Matthew J. Wayner and Kazuo Sasaki},
  journal={Peptides},
  year={2009},
  volume={30 8},
  pages={1487-96}
}
Orexin-A (ORX-A) and orexin-B (ORX-B) play critical roles in the regulation of sleep-wakefulness, energy homeostasis, neuroendocrine system and autonomic functions. Although ORXs are also implicated in the reward process, their electrophysiological effects on neurons in the shell of nucleus accumbems (NAcSh) have not been described thoroughly. Therefore we examined the electrophysiological effects of ORXs on rat NAcSh neurons. Whole cell patch clamp recording in vitro revealed that ORX-A and… CONTINUE READING

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