Electrophysiological effects of locally applied noradrenergic agents at cerebellar Purkinje neurons: receptor specificity

@article{Parfitt1988ElectrophysiologicalEO,
  title={Electrophysiological effects of locally applied noradrenergic agents at cerebellar Purkinje neurons: receptor specificity},
  author={Karen D. Parfitt and Robert Freedman and P C Bickford-Wimer},
  journal={Brain Research},
  year={1988},
  volume={462},
  pages={242-251}
}
We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized Fischer 344 rats. Timolol, a beta-receptor antagonist, did not affect norepinephrine (NE)-induced inhibition in 9 of 12 cells studied. Phentolamine, an alpha-receptor antagonist… CONTINUE READING

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