Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone.

@article{Varr2001ElectrophysiologicalEO,
  title={Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone.},
  author={Andr{\'a}s Varr{\'o} and J{\'a}nos Tak{\'a}cs and Miklos Nemeth and Ott{\'o} H{\'a}la and L{\'a}szl{\'o} Vir{\'a}g and Norbert Iost and Be{\'a}ta Bal{\'a}ti and M{\'a}rta {\'A}goston and Andr{\'a}s Vereckei and G. Prats Pastor and Martine Delbruy{\`e}re and Patrick Gautier and Dino Nisato and Julius Gy Papp},
  journal={British journal of pharmacology},
  year={2001},
  volume={133 5},
  pages={625-34}
}
The electrophysiological effects of dronedarone, a new nonionidated analogue of amiodarone were studied after chronic and acute administration in dog Purkinje fibres, papillary muscle and isolated ventricular myocytes, and compared with those of amiodarone by applying conventional microelectrode and patch-clamp techniques. Chronic treatment with dronedarone (2x25 mg(-1) kg(-1) day p.o. for 4 weeks), unlike chronic administration of amiodarone (50 mg(-1) kg(-1) day p.o. for 4 weeks), did not… CONTINUE READING
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