Electrophysiological effects of cocaine and procaine on dorsal raphe serotonin neurons.

  title={Electrophysiological effects of cocaine and procaine on dorsal raphe serotonin neurons.},
  author={Kathryn A. Cunningham and Joan M. Lakoski},
  journal={European journal of pharmacology},
  volume={148 3},
Dissociable Roles for the Dorsal and Median Raphé in the Facilitatory Effect of 5-HT1A Receptor Stimulation upon Cocaine-Induced Locomotion and Sensitization
While the DRN is involved in the acute effects of cocaine, neuroadaptations in the MRN may regulate the long-term consequences of repeated cocaine exposure.
Cocaine and amphetamine interact at 5-HT synapses through distinct mechanisms in guinea-pig prepositus hypoglossi
  • D. Bobker, J. Williams
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1991
Intracellular recordings were made from guinea-pig prepositus hypoglossi neurons in vitro, finding that the effects of cocaine on IPSP duration can be completely accounted for by inhibition of 5-HT uptake.
Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens
Cocaine produced a larger impact on DA than 5-HT neurotransmission under specific conditions and a series of physiological mechanisms, i.e. terminal density, neurotransmitter interactions and somatodendritic regulation, are discussed as factors responsible for facilitating cocaine's effects on DA relative to 5- HT.
Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia
  • P. Broderick
  • Biology, Chemistry
    Pharmacology Biochemistry and Behavior
  • 1992


Effects of histamine, H1- and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus.
It is indicated that the inhibitory effects of histamine and cimetidine observed in the dorsal raphe nucleus may result, in part, from an action directly or indirectly at a gamma-aminobutyric acid receptor complex.
Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue.
Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.
  • E. Shaskan, S. Snyder
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1970
The findings suggest that doses of 5-HT administered into the brain in a variety of studies may enter catecholaminergic neurons in significant quantities.
The Pharmacological Basis of Therapeutics
On pharmacology and the rational use of drugs, 42 authors share the herculean task of reviewing the flood of recent literature under single or dual authorship and each chapter offers a complete and up-to-date review.