Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem

@article{Leboeuf1989ElectrophysiologicalEO,
  title={Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem},
  author={J. Leboeuf and J. Lamar and R. Massingham and J. Ponsonnaille},
  journal={British Journal of Pharmacology},
  year={1989},
  volume={98}
}
  • J. Leboeuf, J. Lamar, +1 author J. Ponsonnaille
  • Published 1989
  • Chemistry, Medicine
  • British Journal of Pharmacology
    • 1 The electrophysiological effects of bepridil, its quaternary derivative, CERM 11888 (methylpyrrolidinium bromide) (both 2.5 mg kg−1 i.v.) and those of verapamil and diltiazem (0.2 mg kg−1 i.v.) were studied in closed chest anaesthetized dogs at doses used in clinical studies. 2 The four drugs caused a bradycardia with the following order of potency: bepridil > CERM 11888 > diltiazem > verapamil. 3 All the compounds slowed conduction in the AV node, increased the refractory period (RP) and… CONTINUE READING
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