Electrophysiological differences between Purkinje cells in organotypic and granuloprival cerebellar cultures

@article{DrakeBaumann1995ElectrophysiologicalDB,
  title={Electrophysiological differences between Purkinje cells in organotypic and granuloprival cerebellar cultures},
  author={Rosemarie Drake-Baumann and Fredrick John Seil},
  journal={Neuroscience},
  year={1995},
  volume={69},
  pages={467-476}
}
Organotypic cerebellar cultures derived from newborn mice were exposed to cytosine arabinoside for the first five days in vitro to destroy granule cells and functionally compromise glia. Such granuloprival cultures undergo a circuit reorganization featured by Purkinje cells sprouting recurrent axon collaterals that hyperinnervate other Purkinje cells. Intracellular recordings were used to compare the electrophysiological properties of Purkinje cells in granuloprival cultures to those of… CONTINUE READING

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