Electrophysiological correlates of progressive sensorineural pathology in carboplatin-treated chinchillas.

@article{ElBadry2007ElectrophysiologicalCO,
  title={Electrophysiological correlates of progressive sensorineural pathology in carboplatin-treated chinchillas.},
  author={Mohamed Mohamed El-Badry and Sandra L. McFadden},
  journal={Brain research},
  year={2007},
  volume={1134 1},
  pages={122-30}
}
Carboplatin produces progressive damage to auditory nerve fibers, spiral ganglion neurons (SGNs) and inner hair cells (IHC) in the chinchilla cochlea but leaves outer hair cells intact. Within 1 h after injection, many afferent terminals beneath IHCs and myelin lamellae surrounding SGN processes are vacuolated. One day after injection, approximately half of the nerve fibers are missing. IHCs are intact at 2 days, but 20-30% are missing at 3 days. We studied the electrophysiological correlates… CONTINUE READING
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