Electrophysiological consequences of purinergic receptor stimulation in isolated rat pulmonary arterial myocytes.

@article{Hartley1997ElectrophysiologicalCO,
  title={Electrophysiological consequences of purinergic receptor stimulation in isolated rat pulmonary arterial myocytes.},
  author={Shahiem Hartley and Roland Z. Kozlowski},
  journal={Circulation research},
  year={1997},
  volume={80 2},
  pages={170-8}
}
Neither the electrophysiological effects of purinergic receptor stimulation nor the role of ATP in regulating the tone of pulmonary arterial smooth muscle has been determined. Therefore, we investigated the effects of purine nucleotides on acutely dissociated smooth muscle cells from rat small pulmonary arteries using the patch-clamp recording technique. Extracellular application of ATP activated a fast transient inward current (which decayed in the continued presence of the nucleotide) and… CONTINUE READING
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