Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, α2-adrenergic and D2 receptors in the rat brain

@article{Ghanbari2009ElectrophysiologicalCO,
  title={Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, $\alpha$2-adrenergic and D2 receptors in the rat brain},
  author={Ramez Ghanbari and Mostafa El Mansari and Mohammed Shahid and Pierre U. Blier},
  journal={European Neuropsychopharmacology},
  year={2009},
  volume={19},
  pages={177-187}
}
Asenapine is a psychopharmacologic agent being developed for schizophrenia and bipolar disorder. This study electrophysiologically characterized the in vivo effects of asenapine at dorsal raphe nucleus (DRN) and hippocampus serotonin-1A (5-HT(1A)), ventral tegmental area D(2), locus coeruleus 5-HT(2A,) and alpha(2)-adrenergic receptors in anesthetized rats. Asenapine displayed potent antagonistic activity at alpha(2)-adrenoceptors (ED(50), 85+/-2 microg/kg), 5-HT(2A) (ED(50), 75+/-2 microg/kg… Expand
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