Electrophysiological characterization of the class III activity of sotalol and its enantiomers. New interpretation of use-dependent effects.


1. Sotalol (Sotalex) and both its optical isomers were studied in electrophysiological experiments with respect to their class III activity of antiarrhythmic drugs. The three substances prolonged action potentials (AP) of guinea-pig papillary muscle and left atrium in concentrations greater than or equal to 3 mumol/l, whereas other AP parameters (resting… (More)


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