Electrophysiological characterization of diazepam binding inhibitor (DBI) on GABAA receptors.

  title={Electrophysiological characterization of diazepam binding inhibitor (DBI) on GABAA receptors.},
  author={Joachim Bormann},
  volume={30 12B},
The gamma-aminobutyric acid (GABAA) receptor complex is a hetero-oligomeric protein which contains an integral chloride channel and several modulatory domains. The ligands of benzodiazepine recognition sites can up- or down-regulate the activity of the GABAA receptor. The effects of DBI (diazepam binding inhibitor) on GABAA receptors have been studied in cultured mammalian central neurons. Experiments performed with patch-clamp techniques, as well as with conventional intracellular… CONTINUE READING
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