Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain.

@article{Wang1998ElectrophysiologicalCO,
  title={Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain.},
  author={Hong Wang and You-jun Fei and Vadivel Ganapathy and Frederick H. Leibach},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 4},
  pages={C967-C975}
}
We have cloned a peptide transporter from rat brain and found it to be identical to rat kidney PEPT2. In the present study we characterize the transport function of the rat brain PEPT2, with special emphasis on electrophysiological properties and interaction with N-acetyl-l-aspartyl-l-glutamate (NAAG). When heterologously expressed in HeLa cells and in SK-N-SH cells, PEPT2 transports several dipeptides but not free amino acids in the presence of a proton gradient. NAAG competes with other… CONTINUE READING
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Localization and possible functional role of the mammalian di-/tripeptide transporter PEPT2 in brain (Abstract)

  • M. Nickolaus, U. Karbach, M. Herget, H. Koepsell, H. Daniel
  • FASEB J. 12:
  • 1998

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