Electrophysiological characteristics of cholinergic and non-cholinergic neurons in the rat medial septum-diagonal band complex

  title={Electrophysiological characteristics of cholinergic and non-cholinergic neurons in the rat medial septum-diagonal band complex},
  author={Henry Markram and Menahem Segal},
  journal={Brain Research},

Electrophysiological properties of cholinergic and noncholinergic neurons in the ventral pallidal region of the nucleus basalis in rat brain slices.

Cholinergic pallidal neurons in brain slices from 6- to 18-day-old rats have similar properties to magnocellular cholinergic neurons in other parts of the forebrain, except that they exhibit strong spike accommodation.

Physiological Properties of Cholinergic and Non-Cholinergic Magnocellular Neurons in Acute Slices from Adult Mouse Nucleus Basalis

This is the first description of the physiological properties of cholinergic and non-cholinergic neurons in the posterior aspects of the basal forebrain complex and the first study of basal fore brain neurons from the mouse.

Excitatory actions of serotonin on GABAergic neurons of the medial septum and diagonal band of broca

The physiological and pharmacological actions of serotonin (5‐HT) on neurons in the medial septum and diagonal band of Broca (MSDB) were examined using extracellular and intracellular recording techniques in an in vitro rat brain‐slice preparation and novel excitatory actions of 5‐HT on GABA‐type cells were observed.

Loss of rhythmically bursting neurons in rat medial septum following selective lesion of septohippocampal cholinergic system.

Recording in rats after selective destruction of the cholinergic septal neurons by the immunotoxin 192 IgG-saporin suggested that the large majority of the RB sePTal neurons are Cholinergic and that the few neurons that display RB activity in lesioned rats are GABAergic.

Action potentials and relations to the theta rhythm of medial septal neurons in vivo

The results suggest that generation of theta rhythm requires a background of excitatory influences on the hippocampus in combination with the phasic disinhibitory action mediated by the GABAergic MS-DB projection.



Properties of rat medial septal neurones recorded in vitro.

  • M. Segal
  • Biology
    The Journal of physiology
  • 1986
Activity of neurones of the rat medial septal nucleus (m.s.) was recorded in in vitro slice preparations and it was suggested that l.p.s. projects a GABA‐mediated inhibitory connexion to the m.S. neurones in a manner consistent with an increase in K+ conductance.

Membrane properties of cell types within guinea pig basal forebrain nuclei in vitro.

The present study provides a more detailed analysis of the passive and active membrane properties of SAHP and FAHP types within these forebrain nuclei and characterized the passive electrical cable properties of both cell types.

Ionic basis of the differential neuronal activity of guinea‐pig septal nucleus studied in vitro.

The results suggest the existence in intermediate septal neurons of a low‐threshold Ca2+ conductance inactivated at the resting potential and deinactivated by hyperpolarization.

GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus

It is shown that GABA-containing afferents originating in the septum innervate most of the GABA- containing interneurons in the hippocampus, making many synaptic contacts with each of them.

Human memory and the cholinergic system. A relationship to aging?

Comparisons of the memory and cognitive deficits induced by scopolamine with the performance of aged subjects revealed a marked similarity of pattern, and the possible theoretical explanations for the behavioral similarity seen with central cholinergic blockade and normal aging are discussed.