Electrophysiological basis of the reinforcing effects of cocaine.

  title={Electrophysiological basis of the reinforcing effects of cocaine.},
  author={F. J. White},
  journal={Behavioural pharmacology},
  volume={1 4},
The meteoric rise in cocaine abuse over the past decade has led renewed interest in the mechanisms by which this drug produces it potent reinforcing effects. Animal studies have clearly implicated the mesoaccumbens and mesocortical dopamine (DA) neuronal systems as integral brain sites involved in mediating self-administration of cocaine. Biochemical studies have determined that the most reward-relevant action of cocaine within the brain is the inhibition of reuptake of synaptic DA which occurs… CONTINUE READING

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