Electrophysiological and amperometric evidence that modafinil blocks the dopamine uptake transporter to induce behavioral activation

@article{Federici2013ElectrophysiologicalAA,
  title={Electrophysiological and amperometric evidence that modafinil blocks the dopamine uptake transporter to induce behavioral activation},
  author={M. Federici and E. C. Latagliata and F. Rizzo and A. Ledonne and N. Mercuri},
  journal={Neuroscience},
  year={2013},
  volume={252},
  pages={118-124}
}
Although the wake-promoting drug modafinil has been shown to bind quite exclusively to the dopamine transporter (DAT), its action in the brain has been thought to be partially independent from the facilitation of the dopaminergic signals. Here we used electrophysiological and amperometric techniques to investigate the effects of modafinil on the dopaminergic neurons of the substantia nigra pars compacta (SNpc) and on the synaptic overflow of dopamine in the dorsal striatum from the sliced… Expand
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