Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection

  title={Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection},
  author={Natalie Richards and Chris P Wayman and Kelly Ann Allers},
  journal={Neuroscience Letters},
Neuronal activity in the hypothalamic paraventricular nucleus varies across the estrous cycle in anesthetized female rats: effects of dopamine receptor agonism.
This study shows that PVN neuronal activity varies with hormonal state, and these neurons are differentially affected by apomorphine, suggesting two different populations of PVN neurons, and is indicative of a critical role for the PVN in female sexual function.
Comparisons of apomorphine‐induced erection and spontaneous erection in rats by telemetric assessment of intracavernosal pressure
AIE is easy and requires less time than SE measurements, therefore, AIE could be a useful method to evaluate ICP in rats and ICP measurements using a telemetric device showed no significant difference.
Clavulanic acid induces penile erection and yawning in male rats: Comparison with apomorphine
The evaluation of apomorphine for the treatment of erectile dysfunction
Apomorphine is not a first-line treatment option for patients with ED, but may have a niche in the treatment ED in patients who have failed treatment with, or are intolerant to other well-established pharmacological treatment for ED (e.g., PDE5-Is).
The Efficacy of Using Cabergoline in Psychogenic Erectile Dysfunction Treatment (A Local Study)
The use of combination treatment of cabercoline and tadalafil was unscathed and more operative in the treating of patients with psychogenic dysfunction erectile compared to tadalAFil monotherapy.
Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity
Evidence is provided that HHCy is a vascular risk factor for erectile dysfunction by impairing cavernosa endothelial nitric oxide synthase activity and intake of vitamins B can alleviate this abnormality.
Central nervous system agents and erectile dysfunction.
The neurobiology of the male sexual refractory period


Dopaminergic neurotransmission at the paraventricular nucleus of hypothalamus in central regulation of penile erection in the rat.
It is demonstrated that application of apomorphine to the paraventricular nucleus of hypothalamus elicited penile erection in the rat and indicates that PVN may be involved in the central regulation of apomorphicine-induced penile implantation in theRat.
Apomorphine-induced brain modulation during sexual stimulation: a new look at central phenomena related to erectile dysfunction
Functional magnetic resonance imaging placebo-controlled study presents the first in vivo demonstration of the apomorphine-induced modulation of cortical and subcortical brain structures in patients with psychogenic erectile dysfunction, suggesting that psychogenic impotence may be associated with previously unrecognized underlying functional abnormalities of the brain.
Systemic and cavernous plasma levels of vasopressin in healthy males during different functional conditions of the penis
The findings are not in favour of AVP as an important mediator involved in adrenergic neurotransmission in the corpus cavernosum penis, and indicate that the decrease in systemic AVP levels in response to sexual arousal might be a prerequisite to facilitate penile tumescence and rigidity in healthy males.