Electrophysiological actions of somatostatin (SRIF) in hippocampus: Anin vitro study

  title={Electrophysiological actions of somatostatin (SRIF) in hippocampus: Anin vitro study},
  author={Alan L. Mueller and Dennis D. Kunkel and Phillip A. Schwartzkroin},
  journal={Cellular and Molecular Neurobiology},
1. The electrophysiological actions of somatostatin (somatotropin release inhibiting factor; SRIF) were investigated in thein vitro hippocampal slice preparation. Intracellular recordings were obtained from pyramidal neurons in area CA1 in slices of hippocampus from guinea pigs and rabbits. 2. Somatostatin, applied via micropressure ejection to CA1 pyramidal-cell somata, was primarily excitatory. The effects, however, were quite variable, with nearly all cells displaying pronounced… CONTINUE READING


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Somatostatin-14 directly depresses neuronal discharge but enhances excitatory responses to acetylcholine in the rat cortex and hippocampus

  • J. R. Mancillas, G. R. Siggins, P. E. Bloom
  • Soc. Neurosci. Abstr
  • 1985
1 Excerpt

Pro-somatostatin-related peptides alter the discharge rate of rat cortical and hippocampal neurons in vivo: An iontophoretic study

  • G. R. Siggins, E. D. French
  • Soc. Neurosci. Abstr
  • 1984
1 Excerpt

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