Electrophysiological actions of mexiletine on isolated rabbit atria and canine ventricular muscle and purkinje fibres.

Abstract

The electrophysiological effects of varying concentrations of mexiletine on isolated rabbit sinus node and atrial preparations. Purkinje fibres, Purkinje-fibre-ventricular muscle junction and distal conduction system ('gate') were studied in oxygenated Tyrode solution at 35 degrees C using standard microelectrode techniques. 'Therapeutic' concentrations of… (More)

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Cite this paper

@article{Yamaguchi1979ElectrophysiologicalAO, title={Electrophysiological actions of mexiletine on isolated rabbit atria and canine ventricular muscle and purkinje fibres.}, author={I.. Yamaguchi and B. S. Nara Singh and William J. Mandel}, journal={Cardiovascular research}, year={1979}, volume={13 5}, pages={288-96} }