Electrophysiological actions of lidocaine on canine ventricular muscle and Purkinje fibers.

@article{Davis1969ElectrophysiologicalAO,
  title={Electrophysiological actions of lidocaine on canine ventricular muscle and Purkinje fibers.},
  author={L. Douglas Davis and John V. Temte},
  journal={Circulation research},
  year={1969},
  volume={24 5},
  pages={
          639-55
        }
}
Isolated canine papillary muscles with attached false tendons were perfused with Tyrode's solution containing lidocaine. Transmembrane action potentials of ventricular muscle fibers and Purkinje fibers were recorded with glass microelectrodes. Repolarization of Purkinje fibers was accelerated by lidocaine but that of ventricular muscle fibers was unaffected. The maximum rate of rise of the action potential of Purkinje fibers decreased only at 50.0 mg/liter lidocaine; that of ventricular muscle… CONTINUE READING
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