Electrophysiological actions of corticotropin-releasing factor in the central nervous system.

  title={Electrophysiological actions of corticotropin-releasing factor in the central nervous system.},
  author={George Robert Siggins and Donna L. Gruol and Josef Bernd Aldenhoff and Quentin Pittman},
  journal={Federation proceedings},
  volume={44 1 Pt 2},
A review of recent studies of the effects of corticotropin-releasing factor (CRF) on the electrical activity of central neurons indicates that CRF has predominantly excitatory actions in locus ceruleus, hippocampus, cortex, and some regions of hypothalamus. These brain areas are reported to contain immunoreactive CRF. Intracellular recordings in the hippocampal slice preparation demonstrate that the excitation in this preparation may arise from reduction of the afterhyperpolarizations (AHPs… CONTINUE READING


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