Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c *

@article{Shimizu2000ElectrophysiologicalSO,
  title={Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c *},
  author={Seiichi Shimizu and Tomohiro Ide and Taihei Yanagida and Yuichi Tsujimoto},
  journal={The Journal of Biological Chemistry},
  year={2000},
  volume={275},
  pages={12321 - 12325}
}
  • Seiichi Shimizu, Tomohiro Ide, +1 author Yuichi Tsujimoto
  • Published 2000
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • The Bcl-2 family of proteins, consisting of anti-apoptotic and pro-apoptotic members, regulates cell death by controlling mitochondrial membrane permeability that is crucial for apoptotic signal transduction. We have recently shown that some of these proteins, such as Bcl-xL, Bax, and Bak, directly modulate the mitochondrial voltage-dependent anion channel (VDAC) and thus regulate apoptogenic cytochrome crelease and potential loss. To elucidate the molecular mechanisms of VDAC regulation by Bcl… CONTINUE READING

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