Electrophysiological Properties of a Novel Ca2+-Activated K+ Channel Expressed in Human Osteoblasts

@article{Hirukawa2008ElectrophysiologicalPO,
  title={Electrophysiological Properties of a Novel Ca2+-Activated K+ Channel Expressed in Human Osteoblasts},
  author={Koji Hirukawa and Katsuhiko Muraki and Susumu Ohya and Yuji Imaizumi and Akifumi Togari},
  journal={Calcified Tissue International},
  year={2008},
  volume={83},
  pages={222-229}
}
Intracellular Ca2+ mobilization plays important roles in cell survival, proliferation, and differentiation of osteoblasts. In this study, we identified a novel type of Ca2+-activated K+ channel in human osteoblasts and investigated its physiological roles. Using RT-PCR methods and single-channel analysis in the patch-clamp technique, we found that BK and IK channels were genetically expressed in human osteoblasts and had electrophysiological properties similar to those reported previously for… CONTINUE READING

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