Electrophysiologic effects of prazosin during acute myocardial ischemia.

  title={Electrophysiologic effects of prazosin during acute myocardial ischemia.},
  author={David J. Wilber and Joseph J. Lynch and Benedict Robert Lucchesi},
  journal={European journal of pharmacology},
  volume={127 1-2},
Prazosin, 100 micrograms/kg, had no effect on baseline refractoriness or intraventricular conduction in anesthetized dogs. During 1 h of coronary artery occlusion followed by reperfusion, prazosin significantly blunted the shortening of the ventricular effective refractory periods within ischemic myocardial region relative to vehicle-treated animals. Prazosin treatment also prevented the delayed conduction of paced ventricular complexes entering and exiting the ischemic zone. These effects may… CONTINUE READING

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