Electrophysiologic effects of flecainide acetate and its major metabolites in the canine heart.

  title={Electrophysiologic effects of flecainide acetate and its major metabolites in the canine heart.},
  author={J. Guehler and C. Gornick and H. Tobler and A. Almquist and J. R. Schmid and D. Benson and D. Benditt},
  journal={The American journal of cardiology},
  volume={55 6},
  • J. Guehler, C. Gornick, +4 authors D. Benditt
  • Published 1985
  • Medicine
  • The American journal of cardiology
  • Flecainide acetate, an investigational class 1 antiarrhythmic agent, undergoes biotransformation in man with production of 2 major metabolites: meta-O-dealkylated flecainide (S-24623) and the meta-O-dealkylated lactam of flecainide (S-26191). This study compared the effects of flecainide, S-24623 and S-26191 on cardiac electrophysiologic characteristics in the anesthetized dog. Each dog received 2 dose levels of 1 of the 3 test compounds after control measurements. Flecainide (2 and 4 mg/kg in… CONTINUE READING
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