• Corpus ID: 36322972

Electrophysiologic effects of diphenidol in isolated cardiac tissue.

  title={Electrophysiologic effects of diphenidol in isolated cardiac tissue.},
  author={Hiroshi Hayakawa and William J. Mandel},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={185 3},
  • H. HayakawaW. Mandel
  • Published 1 June 1973
  • Biology, Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
Diphenidol, a potent antiemetic, has previously been shown to possess significant antiarrhythmic effects in the intact animal. In the present investigation the effects of diphenidol (1 x 10 -7 to 1 x 10 -4 M) were studied in canine Purkinje fiber and rabbit right atrial preparations. In Purkinje fiber, low concentrations (1 x 10 -7 M) of diphenidol resulted in significant depression of dv/dt , shortening of action potential duration and shift of the membrane responsiveness curve down and to the… 

DìphenidolTreatment of Arrhythmias*

Although antiarrhythmic activity was demonstrated, 14 patients with arrhythmias developed adverse effects related to the nervous system, which were of such severity that the study had to be terminated.

Diphenidol treatment of arrhythmias.

The antiarrhythmic activity of diphenidol, an antiemetic, has been demonstrated both in electrophysiologic studies of patiens and in experimental arrhythmias in animals, and adverse effects related to the central nervous system were of such severity as to suggest that further studies with diphenodol as an antiarrHythmic are not warranted.


Ouabain administration prolonged atrio‐ventricular conduction time in all animals and diphenidol attenuated this effect, suggesting the influence of both drugs on atrioventricular conduction may not be entirely mediated by central neurones.

Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol.