• Corpus ID: 36322972

Electrophysiologic effects of diphenidol in isolated cardiac tissue.

  title={Electrophysiologic effects of diphenidol in isolated cardiac tissue.},
  author={H. Hayakawa and W. Mandel},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={185 3},
  • H. Hayakawa, W. Mandel
  • Published 1 June 1973
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
Diphenidol, a potent antiemetic, has previously been shown to possess significant antiarrhythmic effects in the intact animal. In the present investigation the effects of diphenidol (1 x 10 -7 to 1 x 10 -4 M) were studied in canine Purkinje fiber and rabbit right atrial preparations. In Purkinje fiber, low concentrations (1 x 10 -7 M) of diphenidol resulted in significant depression of dv/dt , shortening of action potential duration and shift of the membrane responsiveness curve down and to the… 

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