Electrophysiologic effects of amiodarone: experimental and clinical observation relative to serum and tissue drug concentrations.

@article{Ikeda1984ElectrophysiologicEO,
  title={Electrophysiologic effects of amiodarone: experimental and clinical observation relative to serum and tissue drug concentrations.},
  author={Nahoko Ikeda and Koonlawee Nademanee and Ravi Kannan and Bramah N. Singh},
  journal={American heart journal},
  year={1984},
  volume={108 4 Pt 1},
  pages={890-8}
}
Oral amiodarone is a potent antiarrhythmic agent with a slow onset of action. Its electrophysiologic properties following chronic administration are well known, but its acute electrophysiologic actions are poorly defined. The objectives of the present study were to correlate the electrophysiologic actions of intravenous amiodarone in humans with the acute and chronic effects of the drug relative to plasma and tissue concentrations of the drug. In humans (n = 10), 5 mg/kg intravenous amiodarone… CONTINUE READING