Electrophoretic signal comparison applied to mRNA differential display analysis.

  title={Electrophoretic signal comparison applied to mRNA differential display analysis.},
  author={Tero Aittokallio and Tapio Pahikkala and Pekka Ojala and Timo J. Nevalainen and Olli Nevalainen},
  volume={34 1},
Gene expression analysis by electrophoretic methods is currently limited by the labor-intensive visual evaluation of the electrophoretic signal profiles. For this purpose, we present a flexible approach to computer-assisted comparison of quantitative electrophoretic patterns between multiple expression signals. Gaussian curves are first fitted to the complex peak mixtures, and the resulting approximate signals are then aligned and compared on a peak-by-peak basis with respect to specific… CONTINUE READING