Electrophoretic component of electric pulses determines the efficacy of in vivo DNA electrotransfer.

@article{atkauskas2005ElectrophoreticCO,
  title={Electrophoretic component of electric pulses determines the efficacy of in vivo DNA electrotransfer.},
  author={Saulius {\vS}atkauskas and Franck Andr{\'e} and Michel Francis Bureau and Daniel Scherman and Damijan Miklavcic and Lluis M. Mir},
  journal={Human gene therapy},
  year={2005},
  volume={16 10},
  pages={1194-201}
}
Efficient DNA electrotransfer can be achieved with combinations of short high-voltage (HV) and long low voltage (LV) pulses that cover two effects of the pulses, namely, target cell electropermeabilization and DNA electrophoresis within the tissue. Because HV and LV can be delivered with a lag up to 3000 sec between them, we considered that it was possible to analyze separately the respective importance of the two types of effects of the electric fields on DNA electrotransfer efficiency. The… CONTINUE READING