Electrophile tocopheryl quinones in apoptosis and mutagenesis: Thermochemolysis of thiol adducts with proteins and in cells

@article{Cornwell2003ElectrophileTQ,
  title={Electrophile tocopheryl quinones in apoptosis and mutagenesis: Thermochemolysis of thiol adducts with proteins and in cells},
  author={D. Cornwell and Sunghwan Kim and Paula A. Mazzer and Kenneth H. Jones and P. Hatcher},
  journal={Lipids},
  year={2003},
  volume={38},
  pages={973-979}
}
Electrophile tocopheryl quinones from the phenolic antioxidants γ-tocopherol and δ-tocopherol form Michael adducts with the thiol nucleophile glutathione. These tocopheryl quinones are involved in cytotoxicity, apoptosis, and mutagenesis, and their biologic properties are associated with the depletion of intracellular thiols. We now show that both proteins and tissues treated with the electrophile γ-tecopheryl quinone (γ-TQ) form thiol adducts. The monoglutathion-S-yl derivative of γ-TQ was… CONTINUE READING

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