Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations.

@article{Mambo2003ElectrophileAO,
  title={Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations.},
  author={Elizabeth Mambo and Xiangqun Gao and Yoram Cohen and Zhong-min Guo and Paul Talalay and David Sidransky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 4},
  pages={1838-43}
}
mtDNA mutations occur in a wide variety of degenerative diseases and cancer. mtDNA seems to be more susceptible to DNA damage and consequently sustains higher rates of mutation than does nuclear DNA (nDNA). Many of the somatic mtDNA mutations in human cancers are located in the displacement loop (D-loop) and in particular in a polycytidine stretch (C-tract) termed D310. The D310 region exhibits polymorphic length variation among individuals and has been described as a "hot spot" for somatic… CONTINUE READING

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