Electronic nicotine delivery systems: is there a need for regulation?

  title={Electronic nicotine delivery systems: is there a need for regulation?},
  author={Anna Trtchounian and Prue Talbot},
  journal={Tobacco Control},
  pages={47 - 52}
Purpose Electronic nicotine delivery systems (ENDS) purport to deliver nicotine to the lungs of smokers. Five brands of ENDS were evaluated for design features, accuracy and clarity of labelling and quality of instruction manuals and associated print material supplied with products or on manufacturers' websites. Methods ENDS were purchased from online vendors and analysed for various parameters. Results While the basic design of ENDS was similar across brands, specific design features varied… 

Electronic nicotine delivery systems: a research agenda

The authors, who cover a broad range of scientific expertise, from basic science to public health, suggest research priorities for non-clinical, clinical and public health studies, and conclude that the first priority is to characterize the safety profile of these products, including in long-term users.

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Nicotine concentrations in electronic cigarette refill and do-it-yourself fluids.

Nicotine concentration labeling on electronic cigarette refill products was often inaccurate but showed improvement recently in products from 1 company, and quality control guidelines for the manufacturing and labeling and to monitor products longitudinally are established.

E-cigarettes, smokers and health policies.

  • S. NardiniR. Pacifici
  • Medicine, Political Science
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  • 2013
The answers to these questions are all “no”: the use of ENDS cannot be considered as “harmless”, and physicians should be very cautious and rely on established smoking cessation drugs.

Nicotine levels in electronic cigarettes 3 Nicotine & Tobacco Research

The principle of the EC is to deliver nicotine in a form of aerosol that does not contain any tobacco specifi c toxins, and is puffed in a similar way to a regular cigarette.

Electronic nicotine delivery system (electronic cigarette) awareness, use, reactions and beliefs: a systematic review

ENDS use is expanding rapidly despite experts’ concerns about safety, dual use and possible ‘gateway’ effects, and more research is needed on effective public health messages, perceived health risks, validity of self-reports of smoking cessation and the use of different kinds of ENDS.

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While e-cigarette aerosol may contain fewer toxicants than cigarette smoke, studies evaluating whether e-cigarettes are less harmful than cigarettes are inconclusive and some evidence suggests that e- cigarette use may facilitate smoking cessation, but definitive data are lacking.


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Effective federal regulation of the manufacturing, packaging, product information and health claims surrounding e-cigarettes is necessary to ensure consumers are presented with accurate e-cigarette use information.



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These articles are unique in that they are the first to have the appearance of conventional tobacco products but contain no tobacco.

Conventional and electronic cigarettes (e-cigarettes) have different smoking characteristics.

The decreased efficiency of aerosol production during e-cigarette smoking makes dosing nonuniform over time and calls into question their usefulness as nicotine delivery devices.

Electronic cigarettes: miracle or menace?

To date, animal and human studies on the health effects of actively or passively smoking e-cigarette are lacking, although three toxicological analyses have been released evaluating various brands of e-cigarettes for their nicotine content and other impurities.

Cigarettes Butts and the Case for an Environmental Policy on Hazardous Cigarette Waste

Several options are available to reduce the environmental impact of cigarette butt waste, including developing biodegradable filters, increasing fines and penalties for littering butts, monetary deposits on filters, increased availability of butt receptacles, and expanded public education.

Electronic cigarettes: safety concerns and regulatory issues.

The wide availability and aggressive marketing of these products may leave health care providers and patients asking an important public health question.

Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.

  • N. Benowitz
  • Biology, Medicine
    Annual review of pharmacology and toxicology
  • 2009
Genetic studies indicate roles for nicotinic receptor subtypes, as well as genes involved in neuroplasticity and learning, in development of dependence, and Pharmacotherapeutic approaches to tobacco addiction include nicotine replacement, bupropion, and varenicline.

Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards

It is shown that residual nicotine from tobacco smoke sorbed to indoor surfaces reacts with ambient nitrous acid (HONO) to form carcinogenic tobacco-specific nitrosamines (TSNAs), which represents an unappreciated health hazard through dermal exposure, dust inhalation, and ingestion.

Variation in, and Causes of, Toxicity of Cigarette Butts to a Cladoceran and Microtox

It was determined that organic compounds caused the majority of toxicity in the cigarette butt leachates, and nicotine and ethylphenol were suspected to be the main causative toxicants.

Nicotine Promotes Tumor Growth and Metastasis in Mouse Models of Lung Cancer

It is shown for the first time that administration of nicotine either by i.p. injection or through over-the-counter dermal patches can promote tumor growth and metastasis in immunocompetent mice.

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

In mouse models of lung cancer and atherosclerosis, it was found that nicotine enhanced lesion growth in association with an increase in lesion vascularity, and these effects were mediated through nicotinic acetylcholine receptors at nicotine concentrations that are pathophysiologically relevant.