Electronic nicotine delivery devices: ineffective nicotine delivery and craving suppression after acute administration

@article{Eissenberg2010ElectronicND,
  title={Electronic nicotine delivery devices: ineffective nicotine delivery and craving suppression after acute administration},
  author={Thomas Eissenberg},
  journal={Tobacco Control},
  year={2010},
  volume={19},
  pages={87 - 88}
}
Electronic nicotine delivery devices (E-cigarettes) are marketed to deliver nicotine without tobacco toxicants and are sold in shopping malls and over the internet despite no published safety or efficacy data.1 2 These unregulated products consist of a battery, heater and cartridge containing a solution of nicotine, propylene glycol and other chemicals.3 Puffing activates the heater and the solution is vaporised and inhaled. Cartridges can be refilled using drops of solution sold in bottles… 

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References

SHOWING 1-10 OF 11 REFERENCES

Evaluating the acute effects of oral, non-combustible potential reduced exposure products marketed to smokers

TLDR
Non-combustible products delivered less nicotine than own brand cigarettes, did not expose smokers to CO and failed to suppress tobacco abstinence symptoms as effectively as combustible products, suggesting that currently marketed non- Combustible PREPs may not be a viable harm reduction strategy for US smokers.

The influence of transdermal nicotine on tobacco/nicotine abstinence and the effects of a concurrently administered cigarette in women and men.

TLDR
Results suggest that TN might need to be combined with other interventions to supplement its effects on tobacco/nicotine abstinence and concurrent smoking.

Tolerance to repeated nicotine administration on performance, subjective, and physiological responses in nonsmokers

TLDR
The hypothesis that nicotine-induced performance enhancement contributes to the reinforcing effects of tobacco use during the early stages of dependence development is not supported.

Ruyan e - cigarette benchtop tests Marketers of electronic cigarettes should halt unproved therapy claims 2008

  • Technical report series : the scientific basis of tobacco product regulation : report of a WHO Study Group
  • 2009

Cigarettes without smoke, or regulation

  • NY Times 2009. http://www.nytimes.com/2009/06/ 02/us/02cigarette.html?_r1⁄41 (accessed
  • 2009

Ruyan e-cigarette bench-top tests

  • Poster presented to the joint conference of the Society for Research on Nicotine and Tobacco and Society for Research on Nicotine and

Ruyan e-cigarette bench-top tests. Poster presented to the joint conference of the Society for Research on Nicotine and Tobacco and Society for Research on

  • Nicotine and Tobacco-Europe; April
  • 2009

Effect of an e - cigarette on craving and withdrawal , acceptability and nicotine delivery : randomized crossover trial

    World Health Organization. Marketers of electronic cigarettes should halt unproved therapy claims