Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors.

@article{Chung2019ElectronicCV,
  title={Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors.},
  author={Samuel Chung and Nathalie Baumlin and John S. Dennis and Robert Moore and Sebastian F. Salathe and P L Whitney and Juan R. Sabater and William M. Abraham and Michael D. Kim and Matthias A Salathe},
  journal={American journal of respiratory and critical care medicine},
  year={2019}
}
RATIONALE Electronic cigarette (e-cig) use has been widely adopted under the perception of safety. [] Key MethodMETHODS Mucociliary parameters were measured in HBECs and in sheep. Systemic nicotine delivery to sheep was quantified using plasma cotinine levels, measured by ELISA. MEASUREMENTS AND MAIN RESULTS In vitro, exposure to e-cig vapor reduced airway surface liquid hydration and increased mucus viscosity of HBECs in a nicotine-dependent manner. Acute nicotine exposure increased intracellular calcium…

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Another Warning Sign: High Nicotine Content in Electronic Cigarettes Disrupts Mucociliary Clearance, the Essential Defense Mechanism of the Lung

  • M. Kesimer
  • Medicine
    American journal of respiratory and critical care medicine
  • 2019
The general misconception by the public that “e-cigarettes are safe,” however, has been challenged or overturned by many recent studies revealing the association between e-cigarettes and adverse cardiovascular, pulmonary, and systemic health effects.

Less burn, more fat: electronic cigarettes and pulmonary lipid homeostasis.

The results of this study identify previously unrecognized adverse effects of ENDS exposure on pulmonary lipid metabolism, although the implication of these effects on long-term respiratory health requires future exploration.

E-cigarette constituents propylene glycol and vegetable glycerin decrease glucose uptake and its metabolism in airway epithelial cells in vitro

Short-term exposure to PG/VG, key components of e-cigarettes, decreased glucose transport and metabolism in airway cells, and it is suggested repeated/chronic exposure to these agents are likely to contribute to airway damage in e-cigarette users.

Evaluation of secondhand smoke effects on CFTR function in vivo

Background Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel expressed on the mucosal surface of epithelial cells lining several tissues including airways. Inherited
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