Electroneutral Cation-Chloride Cotransporters in the Central Nervous System

  title={Electroneutral Cation-Chloride Cotransporters in the Central Nervous System},
  author={Adriana Mercado and David B. Mount and Gerardo Gamba},
  journal={Neurochemical Research},
Several members of the cation-chloride cotransporter (solute carrier family 12, SLC12) gene family are expressed within the central nervous system, with one family member, the K+-Cl− cotransporter KCC2, exclusive to neurons. These transporters are best known for their roles in cell volume regulation and epithelial salt transport, but are increasingly receiving attention in neuroscience. In particular, intracellular chloride activity and hence the neuronal response to GABA and glycine appears to… CONTINUE READING
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Isoforms of the Na-K-2Cl transporter in murine TAL I: Molecular characterization and intrarenal localization

  • D. B. Mount, A. Baekgard, +5 authors S. C. Hebert
  • Am. J. Physiol. Renal Physiol. 276:F347–F358
  • 1999
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Cloning and characterization of SLC12A9, a new member of the cation-chloride cotransporter gene family

  • D. B. Mount, I Arias, Q. Xie, A. Mercado, G. Gamba
  • FASEB J 16:A807
  • 2002
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