Electron transport complex I is required for CD8+ T cell function.

@article{Yi2006ElectronTC,
  title={Electron transport complex I is required for CD8+ T cell function.},
  author={John S. Yi and Beth C. Holbrook and Ryan D. Michalek and Nathan G. Laniewski and Jason M. Grayson},
  journal={Journal of immunology},
  year={2006},
  volume={177 2},
  pages={852-62}
}
After Ag encounter, CD8+ T cells become activated and begin to proliferate. Early during infection, when Ag-specific effector CD8+ T cells are proliferating, producing cytokines, and lysing infected cells in vivo, their mitochondrial potential is increased. The purpose of the experiments presented here was to determine whether mitochondrial function was required for CD8+ T cell function. To block mitochondrial function, transgenic CD8+ T cells were incubated with increasing doses of rotenone… CONTINUE READING