Electron transfer dissociation of peptide anions.

  title={Electron transfer dissociation of peptide anions.},
  author={Joshua J. Coon and Jeffrey Shabanowitz and Donald F. Hunt and John E. P. Syka},
  journal={Journal of the American Society for Mass Spectrometry},
  volume={16 6},
Ion/ion reactions of multiply deprotonated peptide anions with xenon radical cations result in electron abstraction to generate charge-reduced peptide anions containing a free-radical site. Peptide backbone cleavage then occurs by hydrogen radical abstraction from a backbone amide N to facilitate cleavage of the adjacent C-C bond, thereby producing a- and x-type product ions. Introduction of free-radical sites to multiply charged peptides allows access to new fragmentation pathways that are… CONTINUE READING

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