Electron transfer and reaction mechanism of laccases

@article{Jones2014ElectronTA,
  title={Electron transfer and reaction mechanism of laccases},
  author={Stephen E. Jones and Edward I. Solomon},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={72},
  pages={869-883}
}
Laccases are part of the family of multicopper oxidases (MCOs), which couple the oxidation of substrates to the four electron reduction of O2 to H2O. MCOs contain a minimum of four Cu’s divided into Type 1 (T1), Type 2 (T2), and binuclear Type 3 (T3) Cu sites that are distinguished based on unique spectroscopic features. Substrate oxidation occurs near the T1, and electrons are transferred approximately 13 Å through the protein via the Cys-His pathway to the T2/T3 trinuclear copper cluster (TNC… CONTINUE READING

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