Electron tomography of metaphase nucleolar organizer regions: evidence for a twisted-loop organization.

@article{Hliot1997ElectronTO,
  title={Electron tomography of metaphase nucleolar organizer regions: evidence for a twisted-loop organization.},
  author={Laurent H{\'e}liot and Herv{\'e} Kaplan and Laurent Lucas and Christophe Klein and Adrien Beorchia and Martine Doco-Fenzy and Monique Menager and Mark Thiry and M O'donohue and Dominique Ploton},
  journal={Molecular biology of the cell},
  year={1997},
  volume={8 11},
  pages={2199-216}
}
Metaphase nucleolar organizer regions (NORs), one of four types of chromosome bands, are located on human acrocentric chromosomes. They contain r-chromatin, i.e., ribosomal genes complexed with proteins such as upstream binding factor and RNA polymerase I, which are argyrophilic NOR proteins. Immunocytochemical and cytochemical labelings of these proteins were used to reveal r-chromatin in situ and to investigate its spatial organization within NORs by confocal microscopy and by electron… CONTINUE READING

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