Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate.

@article{Nakanishi1998ElectronSR,
  title={Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate.},
  author={Akane Nakanishi and Allan M. Roza and Mark B. Adams and Roman Seibel and G. Moore-Hilton and Balaraman Kalyanaraman and Galen M. Pieper},
  journal={Free radical biology & medicine},
  year={1998},
  volume={25 2},
  pages={201-7}
}
Inhibition of inducible nitric oxide synthase (iNOS) prolongs allograft survival suggesting a role for nitric oxide (.NO) in allograft rejection. Induction of iNOS is regulated by the oxidant-sensitive, nuclear factor kappa B (NF-kappaB) in many cell types. In the present study using electron spin resonance (ESR) spectroscopy, we evaluated whether pyrrolidine dithiocarbamate (PDTC), a metal chelator and antioxidant, might limit .NO production during the development of rejection in cardiac… CONTINUE READING