Electron migration along 5-bromouracil-substituted DNA irradiated in solution and in cells.

Abstract

Solvated electrons generated in aqueous solution after exposure to ionizing radiation can be scavenged by DNA and then transferred along the DNA molecule. This mechanism of charge transfer provides an opportunity for radiation damage to be targeted to certain regions in the DNA molecule and is a mechanism by which single-strand breaks contribute to locally… (More)

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