Electron-microscopic evidence of mitochondriae containing macroautophagy in experimental acute pancreatitis: implications for cell death.

BACKGROUND Dysfunctional autophagy and necrosis are characteristic features of severe acute pancreatitis. OBJECTIVE To unravel the cellular mechanisms underlying the pathogenesis of acute pancreatitis. METHODS We studied the ultrastructural pancreatic morphology using electron microscopy in experimental acute pancreatitis. The control group of animals… CONTINUE READING