Electron microscopic evidence for neurotoxicity in the basal ganglia.

@article{Linder1995ElectronME,
  title={Electron microscopic evidence for neurotoxicity in the basal ganglia.},
  author={J{\"o}rg Linder and Stephen J. Young and Philip M. Groves},
  journal={Neurochemistry international},
  year={1995},
  volume={26 2},
  pages={195-202}
}
The dopaminergic projection from the substantia nigra to the neostriatum is vulnerable to several neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), amphetamine, and 5-hydroxydopamine. We have treated rats or mice with these agents and examined various regions of their brains with a combination of Fink-Heimer, immunohistochemical… CONTINUE READING