Electron microscope observations of the organisation of chromatin fibers in isolated nuclei of rat liver

@article{Heumann2004ElectronMO,
  title={Electron microscope observations of the organisation of chromatin fibers in isolated nuclei of rat liver},
  author={H G Heumann},
  journal={Chromosoma},
  year={2004},
  volume={47},
  pages={133-146}
}
In this study a technique is used which allows observation of chromatin fibers in sections of isolated liver nuclei of the rat. [] Key Result — After application of a preferential ribonucleoproteinstain (EDTA-method) only parts of the fibers retain their stain whereas others are completely bleached. Finer filaments (diameter = 45 Å) seem to be continuous with the stained parts of the chromatin fibers. The RNP-stain is lost when the nuclei have been treated with RNase. From these observations it is concluded…
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