Electron crystallography reveals the structure of metarhodopsin I.

@article{Ruprecht2004ElectronCR,
  title={Electron crystallography reveals the structure of metarhodopsin I.},
  author={Jonathan J Ruprecht and Thorsten Mielke and Reiner Vogel and Claudio Maria Villa and Gebhard F. X. Schertler},
  journal={The EMBO journal},
  year={2004},
  volume={23 18},
  pages={
          3609-20
        }
}
Rhodopsin is the prototypical G protein-coupled receptor, responsible for detection of dim light in vision. Upon absorption of a photon, rhodopsin undergoes structural changes, characterised by distinct photointermediates. Currently, only the ground-state structure has been described. We have determined a density map of a photostationary state highly enriched in metarhodopsin I, to a resolution of 5.5 A in the membrane plane, by electron crystallography. The map shows density for helix 8, the… CONTINUE READING

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