Electron crystallography of proteins in membranes.

  title={Electron crystallography of proteins in membranes.},
  author={Yoshinori Fujiyoshi and Nigel C. Unwin},
  journal={Current opinion in structural biology},
  volume={18 5},
Electron crystallography has played a vital role in advancing our understanding of proteins in membranes since the 'fluid mosaic model' was proposed in 1972. It is now an established technique to reveal the structures of proteins in their natural bilayer environment and makes possible the study of biological mechanisms through freeze-trapping of transitional states. Thus, images and diffraction patterns of well-ordered, planar and tubular protein-lipid crystals are yielding atomic models, which… CONTINUE READING

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