Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions.

@article{Liljeroos2011ElectronCO,
  title={Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions.},
  author={Lassi Liljeroos and Juha T Huiskonen and Ari Ora and Petri Susi and Sarah J Butcher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 44},
  pages={18085-90}
}
Measles virus is a highly infectious, enveloped, pleomorphic virus. We combined electron cryotomography with subvolume averaging and immunosorbent electron microscopy to characterize the 3D ultrastructure of the virion. We show that the matrix protein forms helices coating the helical ribonucleocapsid rather than coating the inner leaflet of the membrane, as previously thought. The ribonucleocapsid is folded into tight bundles through matrix-matrix interactions. The implications for virus… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
35 Citations
47 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

NucleoproteinRNA orientation in the measles virus nucleocapsid by three-dimensional electron microscopy

  • A Desfosses, G Goret, L Farias Estrozi, RWH Ruigrok, I Gutsche
  • J Virol 85:1391–1395
  • 2011

Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein

  • S Gely
  • J Mol Recognit
  • 2010

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR

  • C Bernard
  • FEBS Lett 583:1084–1089
  • 2009

Similar Papers

Loading similar papers…