Electron cryomicroscopy of single particles at subnanometer resolution.

@article{Jiang2005ElectronCO,
  title={Electron cryomicroscopy of single particles at subnanometer resolution.},
  author={Wen Jiang and Steven J. Ludtke},
  journal={Current opinion in structural biology},
  year={2005},
  volume={15 5},
  pages={
          571-7
        }
}
Electron cryomicroscopy and single-particle reconstruction have advanced substantially over the past two decades. There are now numerous examples of structures that have been solved using this technique to better than 10 A resolution. At such resolutions, direct identification of alpha helices is possible and, often, beta-sheet-containing regions can be identified. The most numerous subnanometer resolution structures are the icosahedral viruses, as higher resolution is easier to achieve with… CONTINUE READING

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