Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide

  title={Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide},
  author={K. Holmes and I. Angert and F. J. Kull and W. Jahn and R. Schr{\"o}der},
  • K. Holmes, I. Angert, +2 authors R. Schröder
  • Published 2003
  • Medicine, Chemistry
  • Nature
  • Muscle contraction involves the cyclic interaction of the myosin cross-bridges with the actin filament, which is coupled to steps in the hydrolysis of ATP. While bound to actin each cross-bridge undergoes a conformational change, often referred to as the “power stroke”, which moves the actin filament past the myosin filaments; this is associated with the release of the products of ATP hydrolysis and a stronger binding of myosin to actin. The association of a new ATP molecule weakens the binding… CONTINUE READING
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