Electron-capture dissociation tandem mass spectrometry.

  title={Electron-capture dissociation tandem mass spectrometry.},
  author={Roman A. Zubarev},
  journal={Current opinion in biotechnology},
  volume={15 1},
Electron capture dissociation (ECD) is a new fragmentation technique used in Fourier transform ion cyclotron resonance mass spectrometry and is complementary to traditional tandem mass spectrometry techniques. Disulfide bonds, normally stable to vibrational excitation, are preferentially cleaved in ECD. Fragmentation is fast and specific and labile post-translational modifications and non-covalent bonds often remain intact after backbone bond dissociation. ECD provides more extensive sequence… CONTINUE READING
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Electron capture dissociation of gaseous multiply charged proteins is favored a disulfide bonds and other sites of high hydrogen atom affinity

  • RA Zubarev, NA Kruger, +4 authors FW McLafferty
  • J Am Chem Soc
  • 1999
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