Electron Tomography of the Contact between T Cells and SIV/HIV-1: Implications for Viral Entry

@article{Sougrat2007ElectronTO,
  title={Electron Tomography of the Contact between T Cells and SIV/HIV-1: Implications for Viral Entry},
  author={Rachid Sougrat and Alberto Bartesaghi and Jeffrey D Lifson and Adam E. Bennett and Julian W. Bess and Daniel Zabransky and S. Anand Subramaniam},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={763 - 767}
}
The envelope glycoproteins of primate lentiviruses, including human and simian immunodeficiency viruses (HIV and SIV), are heterodimers of a transmembrane glycoprotein (usually gp41), and a surface glycoprotein (gp120), which binds CD4 on target cells to initiate viral entry. We have used electron tomography to determine the three-dimensional architectures of purified SIV virions in isolation and in contact with CD4+ target cells. The trimeric viral envelope glycoprotein surface spikes are… CONTINUE READING

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